Article
Swimming against ALS: How to model disease in zebrafish for pathophysiological and behavioral studies.
Neuroscience and biobehavioral reviews - 1 May 2023
Oliveira Nuno A S, Pinho Brígida R, Oliveira Jorge M A
Abstract excerpt
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that leads to progressive disability and motor impairment. Existing therapies provide modest improvements in patient survival, raising a need for new treatments for ALS. Zebrafish is a promising model animal for translational and fundamental research in ALS - it is an experimentally tractable vertebrate, with high homology to humans and an ample...
Topics
- Animals
- Humans
- Amyotrophic Lateral Sclerosis
- Zebrafish
- Swimming
- Neurodegenerative Diseases
- Disease Models, Animal
- Superoxide Dismutase-1
- Mutation