Article
Immunohistochemistry as a screening tool for NTRK gene fusions: results of a first Belgian ring trial.
Virchows Archiv : an international journal of pathology - 1 Feb 2021
De Winne Koen, Sorber Laure, Lambin Suzan, Siozopoulou Vasiliki, Beniuga Gabriela, Dedeurwaerdere Franceska, D'Haene Nicky, Habran Lionel, Libbrecht Louis, Van Huysse Jacques, Weynand Birgit, Wouters Katrin, Pauwels Patrick, Zwaenepoel Karen
Abstract excerpt
A Belgian ring trial for pan-TRK immunohistochemistry (IHC) staining was organised to harmonise pan-TRK IHC staining protocols and interpretation. As a reference method, the VENTANA pan-TRK Assay (clone EPR17341) on the Benchmark Ultra platform was selected. Six samples were selected: 2 negative, 2 fusion positive and 2 samples with wild-type endogenous TRK expression. Each participating laboratory stained the...
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