Article

Combinatorial mRNA vaccination enhances protection against SARS-CoV-2 delta variant

2021-12-09

Abstract excerpt

Emergence of SARS-CoV-2 variants of concern (VOC), including the highly transmissible delta strain, has posed challenges to current COVID-19 vaccines that principally target the viral spike protein (S). Here, we report a nucleoside-modified mRNA vaccine that expresses the more conserved viral nucleoprotein (mRNA-N). We show that mRNA-N alone was able to induce a modest but significant control of SARS-CoV-2 in mice...

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Literature Corpus work: 6e15a5a9-3cc8-513d-a623-844511c7bf3d
DOI: 10.1101/2021.12.08.471664

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