Article
Evolution of isoprenyl diphosphate synthase-like terpene synthases in fungi.
Scientific reports - 10 Sept 2020
Wei Guo, Eberl Franziska, Chen Xinlu, Zhang Chi, Unsicker Sybille B, Köllner Tobias G, Gershenzon Jonathan, Chen Feng
Abstract excerpt
Terpene synthases (TPSs) and trans-isoprenyl diphosphate synthases (IDSs) are among the core enzymes for creating the enormous diversity of terpenoids. Despite having no sequence homology, TPSs and IDSs share a conserved "α terpenoid synthase fold" and a trinuclear metal cluster for catalysis, implying a common ancestry with TPSs hypothesized to evolve from IDSs anciently. Here we report on the identification and...
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