Article

Genomic fitness profiling of Acinetobacter baumannii reveals modes of action for common biocides and mechanisms of biocide-antibiotic antagonism

2021-02-09

Abstract excerpt

<title>Abstract</title> Biocides, such as antiseptics and disinfectants, are used ubiquitously for hygiene in households and for life-saving infection control in hospitals. An increasing concern is that the widespread use of biocides may contribute to the emergence and spread of multidrug-resistant bacteria. We performed transposon directed insertion site sequencing (TraDIS) to identify genes and key cellular...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d8be01ac-a70b-57da-a8ba-184ff43baa84
DOI: 10.21203/rs.3.rs-157820/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genomic fitness profiling of Acinetobacter baumannii reveals modes of action for common biocides and mechanisms of biocide-antibiotic antagonismDOI 10.21203/rs.3.rs-157820/v1Read

Antibiotic susceptibility signatures identify potential antimicrobial targets in the Acinetobacter baumannii cell envelope.Semantic proximity Read

Multiple adaptive routes of Salmonella enterica Typhimurium to biocide and antibiotic exposure.Semantic proximity Read

The Acinetobacter baumannii virulence factor Omp33 is important for tolerance to benzalkonium chlorideSemantic proximity Read

Clinical and laboratory-induced colistin-resistance mechanisms in Acinetobacter baumanniiSemantic proximity Read

Genomic sequencing of a strain of Acinetobacter baumannii and potential mechanisms to antibiotics resistance.Semantic proximity Read

Tetrasodium EDTA disrupts Pseudomonas aeruginosa membrane integrity, shows suppressed resistance evolution and reduced cytotoxicity compared to meropenemSemantic proximity Read

Comparative transcriptomic and phenotypic analysis of the responses of Bacillus cereus to various disinfectant treatments.Semantic proximity Read

Chemical genomics informs antibiotic and essential gene function in Acinetobacter baumanniiSemantic proximity Read

Development of Nanoparticle Adaptation Phenomena in Acinetobacter baumannii: Physiological Change and Defense Response.Semantic proximity Read

Parallel evolutionary pathways to antibiotic resistance selected by biocide exposure.Semantic proximity Read

Reduced susceptibility to biocides in Acinetobacter baumannii: association with resistance to antimicrobials, epidemiological behaviour, biological cost and effect on the expression of genes encoding porins and efflux pumps.Semantic proximity Read

The commercial antimicrobial triclosan induces high levels of antibiotic tolerance in vitro and reduces antibiotic efficacy up to 100-fold in vivoSemantic proximity Read