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Article

Novel molecular mechanism of cellular transformation by a mutant molecular chaperone in myeloproliferative neoplasms

25 Jul 2017

Abstract excerpt

Deregulation of the cytokine-receptor signaling pathway plays a significant role in tumorigenesis. Such deregulation is frequently caused by alterations in the genes involved in the signaling pathway. At the end of 2013, recurrent somatic mutations in the calreticulin (CALR) gene that encodes a molecular chaperone were identified in a subset of patients with Philadelphia-chromosome negative myeloproliferative...

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PMID: 28741795
DOI: 10.1111/cas.13327

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