Article
Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation.
Leukemia - 1 Jan 2019
Araki Marito, Yang Yinjie, Imai Misa, Mizukami Yoshihisa, Kihara Yoshihiko, Sunami Yoshitaka, Masubuchi Nami, Edahiro Yoko, Hironaka Yumi, Osaga Satoshi, Ohsaka Akimichi, Komatsu Norio
Abstract excerpt
Studies have previously shown that mutant calreticulin (CALR), found in a subset of patients with myeloproliferative neoplasms (MPNs), interacts with and subsequently promotes the activation of the thrombopoietin receptor (MPL). However, the molecular mechanism behind the activity of mutant CALR remains unknown. Here we show that mutant, but not wild-type, CALR interacts to form a homomultimeric complex. This...
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