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Article

Hsa-miR-155-5p Up-Regulation in Breast Cancer and Its Relevance for Treatment With Poly[ADP-Ribose] Polymerase 1 (PARP-1) Inhibitors

12 Aug 2020

Abstract excerpt

miR-155-5p is a well-known oncogenic microRNA, showing frequent overexpression in human malignancies, including breast cancer. Here, we show that high miR-155-5p levels are associated with unfavorable prognostic factors in two independent breast cancer cohorts (CSS cohort, n=283; and TCGA-BC dataset, n=1095). Consistently, miR-155-5p results as differentially expressed in the breast cancer subgroups identified by...

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PMID: 32903519
DOI: 10.3389/fonc.2020.01415

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