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Article

miR-506: a regulator of chemo-sensitivity through suppression of the RAD51-homologous recombination axis

14 Sept 2015

Abstract excerpt

Ovarian carcinoma is the most lethal gynecologic malignancy. Resistance to platinum is considered the major problem affecting prognosis. Our recent study established that microRNA-506 (miR-506) expression was closely associated with progression-free survival and overall survival in two independent patient cohorts totaling 598 epithelial ovarian cancer cases. Further functional study demonstrated that miR-506...

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PMID: 26369335
DOI: 10.1186/s40880-015-0049-z

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