Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Chemokine Receptor CXCR4 is Regulated by DNA Methylation in Pancreatic Cancer

1 Jan 2005

Abstract excerpt

Despite the biological and clinical importance of the interaction between the chemokine receptor CXCR4 and its ligand CXCL12 (SDF-1alpha) in human cancers, little is known about transcriptional regulation of the CXCR4 gene. Although aberrant hypermethylation in cancer has been described typically in genes with tumor-suppressor properties, this epigenetic alteration has also been observed to affect potential...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Immune cells in cancer
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15662133
DOI: 10.4161/cbt.4.1.1378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Chemokine Receptor CXCR4 is Regulated by DNA Methylation in Pancreatic CancerPMID 15662133Read ↗

Epigenetic Changes of CXCR4 and Its Ligand CXCL12 as Prognostic Factors for Sporadic Breast CancerSemantic proximity Read ↗

Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progressionSemantic proximity Read ↗

Epigenetic inactivation of IRX4 is responsible for acceleration of cell growth in human pancreatic cancerSemantic proximity Read ↗

DNA methylation profiling of the X chromosome reveals an aberrant demethylation on CXCR3 promoter in primary biliary cirrhosisSemantic proximity Read ↗

Enhanced CXCR4 Expression Associates with Increased Gene Body 5-Hydroxymethylcytosine Modification but not Decreased Promoter Methylation in Colorectal CancerSemantic proximity Read ↗

Hypermethylation of CXCR4 promoter in CD34+ cells from patients with primary myelofibrosis.Semantic proximity Read ↗

Genome-wide profiling at methylated promoters in pancreatic adenocarcinomaSemantic proximity Read ↗

Genome-Wide Analysis of Promoter Methylation Associated with Gene Expression Profile in Pancreatic AdenocarcinomaSemantic proximity Read ↗

DNMT1 Inhibition Reprograms Pancreatic Cancer Stem Cells via Upregulation of the miR-17-92 ClusterSemantic proximity Read ↗

Association of CXCR4 gene expression and promoter methylation with chronic hepatitis B-related fibrosis/cirrhosisSemantic proximity Read ↗

Data Mining Suggests That CXCL14 Gene Silencing in Colon Cancer Is Due to Promoter MethylationSemantic proximity Read ↗

Data Mining Suggests that CXCL14 Gene Silencing in Colon Cancer is Due to Promoter MethylationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.