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DNA hypo-methylation and expression of GBP4 induces T cell exhaustion in pancreatic cancer

7 Aug 2024

Abstract excerpt

Immunotherapy for pancreatic ductal carcinoma (PDAC) remains disappointing due to the repressive tumor microenvironment and T cell exhaustion, in which the roles of interferon-stimulated genes were largely unknown. Here, we focused on a typical interferon-stimulated gene, GBP4, and investigated its potential diagnostic and therapeutic value in pancreatic cancer. Expression analysis on both local samples and...

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PMID: 39110249
DOI: 10.1007/s00262-024-03786-3

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