Article
Common germline variation at the TERT locus contributes to familial clustering of myeloproliferative neoplasms.
American journal of hematology - 1 Dec 2014
Jäger Roland, Harutyunyan Ashot S, Rumi Elisa, Pietra Daniela, Berg Tiina, Olcaydu Damla, Houlston Richard S, Cazzola Mario, Kralovics Robert
Abstract excerpt
The C allele of the rs2736100 single nucleotide polymorphism located in the second intron of the TERT gene has recently been identified as a susceptibility factor for myeloproliferative neoplasms (MPN) in the Icelandic population. Here, we evaluate the role of TERT rs2736100_C in sporadic and familial MPN in the context of the previously identified JAK2 GGCC predisposition haplotype. We have confirmed the TERT...
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