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Genetically Determined Telomere Length Is Associated with Pancreatic Neuroendocrine Neoplasms Onset.

Neuroendocrinology - 1 Jan 2022

Gentiluomo Manuel, Capurso Gabriele, Morelli Luca, Ermini Stefano, Pasquali Claudio, Latiano Anna, Tavano Francesca, Greenhalf William, Milanetto Anna Caterina, Landi Stefano, Roth Susanne, Malecka-Wojciesko Ewa, Costello Eithne, Jamroziak Krzysztof, Perri Francesco, Boggi Ugo, Basso Daniela, Farinati Fabio, Kaaks Rudolf, Vanella Giuseppe, Gais Zurcher Anna-Lea J, Archibugi Livia, Lawlor Rita T, Canzian Federico, Campa Daniele

Abstract excerpt

INTRODUCTION: Telomere length (TL) is a potential indicator of cancer predisposition; however, the multitude of techniques used to measure it causes the results to be heterogeneous and, in some cases, controversial. In the last years, several studies adopted a strategy based on TL-associated genetic variants to generate a polygenic score, often referred as teloscore, used in lieu of direct TL measurement. For...

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PMID: 35472852
DOI: 10.1159/000524659

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