Article
Long-term data on two sisters with C3GN due to an identical, homozygous CFH mutation and autoantibodies.
Clinical nephrology - 1 Oct 2020
Hackl Agnes, Erger Florian, Skerka Christine, Wenzel Andrea, Tschernoster Nikolai, Ehren Rasmus, Burgmaier Kathrin, Riehmer Vera, Licht Christoph, Kirschfink Michael, Weber Lutz T, Altmueller Janine, Zipfel Peter F, Habbig Sandra
Abstract excerpt
C3 glomerulonephritis (C3GN) is a rare but severe form of kidney disease caused by fluid-phase dysregulation of the alternative complement pathway. Causative mutations in complement regulating genes as well as auto-immune forms of C3GN have been described. However, therapy and prognosis in individual patients remain a matter of debate and long-term data are scarce. This also applies for the management of...
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