Article
C3 glomerulonephritis secondary to mutations in factors H and I: rapid recurrence in deceased donor kidney transplant effectively treated with eculizumab.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Dec 2018
Garg Neetika, Zhang Yuzhou, Nicholson-Weller Anne, Khankin Eliyahu V, Borsa Nicolò Ghiringhelli, Meyer Nicole C, McDermott Susan, Stillman Isaac E, Rennke Helmut G, Smith Richard J, Pavlakis Martha
Abstract excerpt
Background: C3 glomerulonephritis (C3GN) is caused by alternate complement pathway over-activation. It frequently progresses to end-stage renal disease, recurs in two-thirds of transplants and in half of these cases progresses to allograft loss. There is currently no proven treatment for C3GN. Case Presentation: We describe a family segregating pathogenic alleles of complement factor H and I (CFH and CFI). The...
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