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Article

Monitoring Arteriovenous Malformation Response to Genotype-Targeted Therapy.

Pediatrics - 1 Sept 2020

Edwards Emily A, Phelps Andrew S, Cooke Daniel, Frieden Ilona J, Zapala Matthew A, Fullerton Heather J, Shimano Kristin A

Abstract excerpt

Arteriovenous malformations (AVMs) have recently been reported to have a high incidence of somatic KRAS mutations suggesting potential for treatment with mitogen-activated protein kinase inhibitors. In this case report, we describe genotype-targeted treatment of a KRAS mutant metameric AVM in a patient with Cobb syndrome using the mitogen-activated protein kinase inhibitor trametinib. Therapeutic response was...

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Identifiers

PMID: 32859736
DOI: 10.1542/peds.2019-3206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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