Article
Predicting β-lactam resistance using whole genome sequencing in Klebsiella pneumoniae: the challenge of β-lactamase inhibitors.
Diagnostic microbiology and infectious disease - 1 Nov 2020
Hujer Andrea M, Long S Wesley, Olsen Randall J, Taracila Magdalena A, Rojas Laura J, Musser James M, Bonomo Robert A
Abstract excerpt
Although multiple antimicrobial resistance (AMR) determinants can confer the same in vitro antimicrobial susceptibility testing (AST) phenotype, their differing effect on optimal therapeutic choices is uncertain. Using a large population-based collection of clinical strains spanning a 3.5-year period, we applied WGS to detect inhibitor resistant (IR), extended-spectrum β-lactamase (ESBL), and carbapenem resistant...
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