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Article

Defining the "Frequent Exacerbator" Phenotype in COPD: A Hypothesis-Free Approach.

Chest - 1 May 2018

Le Rouzic Olivier, Roche Nicolas, Cortot Alexis B, Tillie-Leblond Isabelle, Masure Frédéric, Perez Thierry, Boucot Isabelle, Hamouti Latifa, Ostinelli Juliette, Pribil Céline, Poutchnine Christine, Schück Stéphane, Pouriel Mathilde, Housset Bruno

Abstract excerpt

BACKGROUND: The COPD "frequent exacerbator" phenotype is usually defined by at least two treated exacerbations per year and is associated with a huge impact on patient health. However, existence of this phenotype and corresponding thresholds still need to be formally confirmed by statistical methods analyzing exacerbation profiles with no specific a priori hypothesis. The aim of this study was to confirm the...

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PMID: 29054347
DOI: 10.1016/j.chest.2017.10.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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