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Article

Characterization of the "Frequent Exacerbator Phenotype" in Bronchiectasis.

American journal of respiratory and critical care medicine - 1 Jun 2018

Chalmers James D, Aliberti Stefano, Filonenko Anna, Shteinberg Michal, Goeminne Pieter C, Hill Adam T, Fardon Thomas C, Obradovic Dusanka, Gerlinger Christoph, Sotgiu Giovanni, Operschall Elisabeth, Rutherford Robert M, Dimakou Katerina, Polverino Eva, De Soyza Anthony, McDonnell Melissa J

Abstract excerpt

RATIONALE: Exacerbations are key events in the natural history of bronchiectasis, but clinical predictors and outcomes of patients with frequently exacerbating disease are not well described. OBJECTIVES: To establish if there is a "frequent exacerbator phenotype" in bronchiectasis and the impact of exacerbations on long-term clinical outcomes. METHODS: We studied patients with bronchiectasis enrolled from 10...

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PMID: 29357265
DOI: 10.1164/rccm.201711-2202OC

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