Article
Susceptibility to exacerbation in chronic obstructive pulmonary disease.
The New England journal of medicine - 16 Sept 2010
Hurst John R, Vestbo Jørgen, Anzueto Antonio, Locantore Nicholas, Müllerova Hana, Tal-Singer Ruth, Miller Bruce, Lomas David A, Agusti Alvar, Macnee William, Calverley Peter, Rennard Stephen, Wouters Emiel F M, Wedzicha Jadwiga A
Abstract excerpt
BACKGROUND: Although we know that exacerbations are key events in chronic obstructive pulmonary disease (COPD), our understanding of their frequency, determinants, and effects is incomplete. In a large observational cohort, we tested the hypothesis that there is a frequent-exacerbation phenotype of COPD that is independent of disease severity. METHODS: We analyzed the frequency and associations of exacerbation in...
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