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Article

mTORC1 Is Not Principally Involved in the Induction of Human Endotoxin Tolerance.

Frontiers in immunology - 1 Jan 2020

Ludwig Kristin, Husain Ralf A, Rubio Ignacio

Abstract excerpt

Endotoxin tolerance represents a safeguard mechanism for preventing detrimental prolonged inflammation and exaggerated immune/inflammatory responses from innate immune cells to recurrent harmless pathogens. On the other hand, excessive immune tolerance can contribute to pathological immunosuppression, e.g., as present in sepsis. Monocyte activation is accompanied by intracellular metabolic rearrangements that are...

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Identifiers

PMID: 32849516
DOI: 10.3389/fimmu.2020.01515
PMCID: PMC7426365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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