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Spatial organization of Clostridium difficile S-layer biogenesis

24 Aug 2020

Abstract excerpt

Surface layers (S-layers) are protective protein coats which form around all archaea and most bacterial cells. Clostridium difficile is a Gram-positive bacterium with an S-layer covering its peptidoglycan cell wall. The S-layer in C. difficile is constructed mainly of S-layer protein A (SlpA), which is a key virulence factor and an absolute requirement for disease. S-layer biogenesis is a complex multi-step...

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PMID: 32839524
DOI: 10.1038/s41598-020-71059-x

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