Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate.

doi:10.1038/s41467-020-17880-4

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Article

Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate.

Nature communications - 24 Aug 2020

Pandey Akhilesh, Stawiski Eric W, Durinck Steffen, Gowda Harsha, Goldstein Leonard D, Barbhuiya Mustafa A, Schröder Markus S, Sreenivasamurthy Sreelakshmi K, Kim Sun-Whe, Phalke Sameer, Suryamohan Kushal, Lee Kayla, Chakraborty Papia, Kode Vasumathi, Shi Xiaoshan, Chatterjee Aditi, Datta Keshava, Khan Aafaque A, Subbannayya Tejaswini, Wang Jing, Chaudhuri Subhra, Gupta Sanjiv, Shrivastav Braj Raj, Jaiswal Bijay S, Poojary Satish S, Bhunia Shushruta, Garcia Patricia, Bizama Carolina, Rosa Lorena, Kwon Wooil, Kim Hongbeom, Han Youngmin, Yadav Thakur Deen, Ramprasad Vedam L, Chaudhuri Amitabha, Modrusan Zora, Roa Juan Carlos, Tiwari Pramod Kumar, Jang Jin-Young, Seshagiri Somasekar

Abstract excerpt

Gallbladder cancer (GBC) is an aggressive gastrointestinal malignancy with no approved targeted therapy. Here, we analyze exomes (n = 160), transcriptomes (n = 115), and low pass whole genomes (n = 146) from 167 gallbladder cancers (GBCs) from patients in Korea, India and Chile. In addition, we also sequence samples from 39 GBC high-risk patients and detect evidence of early cancer-related genomic lesions. Among...

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PMID: 32839463
DOI: 10.1038/s41467-020-17880-4
PMCID: PMC7445288

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