Article
An Opaque Cell-Specific Expression Program of Secreted Proteases and Transporters Allows Cell-Type Cooperation in Candida albicans.
Genetics - 1 Oct 2020
Lohse Matthew B, Brenes Lucas R, Ziv Naomi, Winter Michael B, Craik Charles S, Johnson Alexander D
Abstract excerpt
An unusual feature of the opportunistic pathogen Candida albicans is its ability to switch stochastically between two distinct, heritable cell types called white and opaque. Here, we show that only opaque cells, in response to environmental signals, massively upregulate a specific group of secreted proteases and peptide transporters, allowing exceptionally efficient use of proteins as sources of nitrogen. We...
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