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Article

Essential role of amino acids in αD-β4 loop of a Bacillus thuringiensis Cyt2Aa2 toxin in binding and complex formation on lipid membrane.

Toxicon : official journal of the International Society on Toxinology - 1 Nov 2013

Suktham Kunat, Pathaichindachote Wanwarang, Promdonkoy Boonhiang, Krittanai Chartchai

Abstract excerpt

Bacillus thuringiensis subsp. darmstadiensis produces Cyt2Aa2 toxin that shows in vivo specific toxicity against Dipteran insect larvae but exhibits in vitro cytolytic activity to a broad-spectrum of cells including red blood cells. Two mutant toxins have been generated by introducing a small hydrophobic alanine into positions Thr-144 and Asn-145 in αD-β4 loop. Both mutants were highly expressed as crystalline...

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PMID: 23988392
DOI: 10.1016/j.toxicon.2013.08.053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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