Article
Serological responses to a soluble recombinant chimeric Plasmodium vivax circumsporozoite protein in VK210 and VK247 population.
Malaria journal - 14 Sept 2013
Cheng Yang, Ito Daisuke, Sattabongkot Jetsumon, Lim Chae Seung, Kong Deok-Hoon, Ha Kwon-Soo, Wang Bo, Tsuboi Takafumi, Han Eun-Taek
Abstract excerpt
BACKGROUND: Circumsporozoite protein (CSP) is essential for sporozoite formation and sporozoite invasion into human hepatocyte. Previously, a recombinant P. vivax CSP based on chimeric repeats (rPvCSP-c) representing two major alleles VK210 and VK247 within central region has been designed. Naturally acquired humoral immune responses study show that antigenicity of rPvCSP-c was much higher than that of native...
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