Article
Reverse genetics approaches for hepatitis E virus and related viruses.
Current opinion in virology - 1 Oct 2020
Scholz Johannes, Falkenhagen Alexander, Bock Claus-Thomas, Johne Reimar
Abstract excerpt
The hepatitis E virus (HEV) is the causative agent of acute and chronic hepatitis in humans. Related viruses have been found in several animal species. Reverse genetics systems (RGSs), which enable the generation of infectious virus from cloned cDNA by transfection of cultured cells or intrahepatic injection into laboratory animals, have been developed for HEV genotypes 1, 3, 4, 5 and 7 as well as for avian HEV...
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