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Revisiting the Mongolian Gerbil Model for Hepatitis E Virus by Reverse Genetics

1 Mar 2022

Abstract excerpt

HEV infects >20 million people annually, causing acute viral hepatitis as well as chronic hepatitis, neurological diseases, and pregnancy-associated high mortality, which require therapeutic intervention. The HEV antiviral research is largely limited by the lack of a convenient small animal model. Here we revisit the Mongolian gerbil model for three genotypes of human HEV by infectious HEV clones and recognized...

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PMID: 35230152
DOI: 10.1128/spectrum.02193-21

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