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Article

Down-regulation of tenascin-C inhibits breast cancer cells development by cell growth, migration, and adhesion impairment

20 Aug 2020

Abstract excerpt

Tenascin-C (TNC) is an extracellular matrix (ECM) glycoprotein that plays an important role in cell proliferation, migration, and tumour invasion in various cancers. TNC is one of the main protein overexpressed in breast cancer, indicating a role for this ECM molecule in cancer pathology. In this study we have evaluated the TNC loss-off-function in breast cancer cells. In our approach, we used dsRNA sharing...

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PMID: 32817625
DOI: 10.1371/journal.pone.0237889

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