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Exploring the virulence gene interactome with CRISPR/dCas9 in the human malaria parasite

1 Aug 2020

Abstract excerpt

Mutually exclusive expression of the var multigene family is key to immune evasion and pathogenesis in Plasmodium falciparum, but few factors have been shown to play a direct role. We adapted a CRISPR-based proteomics approach to identify novel factors associated with var genes in their natural chromatin context. Catalytically inactive Cas9 ("dCas9") was targeted to var gene regulatory elements,...

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PMID: 32816370
DOI: 10.15252/msb.20209569

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