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Epigenetic editing by CRISPR/dCas9 in Plasmodium falciparum

24 Dec 2018

Abstract excerpt

Genetic manipulation remains a major obstacle for understanding the functional genomics of the deadliest malaria parasite Plasmodium falciparum . Although the CRISPR/Cas9 (clustered regularly interspaced short palindromic repeat/CRISPR-associated protein 9) system has been successfully applied to introduce permanent changes in the parasite genome, its use is still limited. Here we show that fusing different...

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PMID: 30584102
DOI: 10.1073/pnas.1813542116

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