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Article

NF1 germline mutation in a Chinese family with colon cancer.

The Journal of international medical research - 1 Aug 2020

Lou Haizhou, Zhai Chongya, Gong Liu, Pan Hong, Pan Hongming, Zhang Yihong, Yang Mei, Hu Zimin

Abstract excerpt

Colorectal cancer (CRC) is a leading cause of cancer death worldwide. Recent advances in genomic medicine have identified novel gene mutations that contribute to an increased risk of CRC. Here, we describe a diagnosis of colon cancer in a 63-year-old woman and also in her brother. Next-generation sequencing showed that both patients harbored a germline mutation in NF1. The female patient also carried co-mutations...

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Identifiers

PMID: 32814491
DOI: 10.1177/0300060519896435
PMCID: PMC7444156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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