Article
A decrease in NAMPT activity impairs basal PARP-1 activity in cytidine deaminase deficient-cells, independently of NAD.
Scientific reports - 17 Aug 2020
Silveira Sandra Cunha, Buhagiar-Labarchède Géraldine, Onclercq-Delic Rosine, Gemble Simon, Bou Samra Elias, Mameri Hamza, Duchambon Patricia, Machon Christelle, Guitton Jérôme, Amor-Guéret Mounira
Abstract excerpt
Cytidine deaminase (CDA) deficiency causes pyrimidine pool disequilibrium. We previously reported that the excess cellular dC and dCTP resulting from CDA deficiency jeopardizes genome stability, decreasing basal poly(ADP-ribose) polymerase 1 (PARP-1) activity and increasing ultrafine anaphase bridge (UFB) formation. Here, we investigated the mechanism underlying the decrease in PARP-1 activity in CDA-deficient...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.