Genetic susceptibility of increased intestinal permeability is associated with progressive liver disease and diabetes in patients with non-alcoholic fatty liver disease.

doi:10.1016/j.numecd.2020.06.013

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Article

Genetic susceptibility of increased intestinal permeability is associated with progressive liver disease and diabetes in patients with non-alcoholic fatty liver disease.

Nutrition, metabolism, and cardiovascular diseases : NMCD - 30 Oct 2020

Miele Luca, Giorgio Valentina, Liguori Antonio, Petta Salvatore, Pastorino Roberta, Arzani Dario, Alberelli Maria A, Cefalo Consuelo, Marrone Giuseppe, Biolato Marco, Rapaccini Gianludovico, Boccia Stefania, Gasbarrini Antonio, Craxì Antonio, Grieco Antonio

Abstract excerpt

BACKGROUND AND AIM: Increased intestinal permeability plays a key role in the pathogenesis of fat deposition in the liver. The aim of our study was to assess whether a single nucleotide polymorphism of protein tyrosine phosphatase non-receptor type 2 (PTPN2) (rs2542151 T→G), involved in intestinal permeability, may be associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM)....

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PMID: 32807638
DOI: 10.1016/j.numecd.2020.06.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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