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Anti-Cancer Immunotherapies Targeting Telomerase

12 Aug 2020

Abstract excerpt

Telomerase is a reverse transcriptase that maintains telomeres length, compensating for the attrition of chromosomal ends that occurs during each replication cycle. Telomerase is expressed in germ cells and stem cells, whereas it is virtually undetectable in adult somatic cells. On the other hand, telomerase is broadly expressed in the majority of human tumors playing a crucial role in the replicative behavior...

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PMID: 32806719
DOI: 10.3390/cancers12082260

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