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Therapeutic Targeting of Telomerase

21 Jul 2016

Abstract excerpt

Telomere length and cell function can be preserved by the human reverse transcriptase telomerase (hTERT), which synthesizes the new telomeric DNA from a RNA template, but is normally restricted to cells needing a high proliferative capacity, such as stem cells. Consequently, telomerase-based therapies to elongate short telomeres are developed, some of which have successfully reached the stage I in clinical...

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PMID: 27455328
DOI: 10.3390/genes7070039

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