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Article

Cytotoxic T cell immunity against telomerase reverse transcriptase in humans

4 Apr 2000

Abstract excerpt

Telomerase is a ribonucleoprotein enzyme which has been linked to malignant transformation in human cells. Telomerase activity is increased in the vast majority of human tumors, making its gene product the first molecule common to all human tumors. The generation of endogenously processed telomerase peptides bound to Class I MHC molecules could therefore target cytotoxic T lymphocytes (CTL) to tumors of different...

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PMID: 10759561
DOI: 10.1073/pnas.070560797

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