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Article

Consistent and idiosyncratic pleiotropy in shaping genetic correlations.

Molecular biology and evolution - 1 Sept 2026

Cai Haoran, Geiler-Samerotte Kerry, Des Marais David L

Abstract excerpt

Pleiotropy, the phenomenon where a single mutation influences multiple phenotypic traits, creates genetic correlations that can constrain evolutionary trajectories. Yet genetic correlations differ in their persistence: some remain stable over long evolutionary timescales, whereas others change rapidly across generations or environments. One explanation is that similar values of genetic correlation, rG, can arise...

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Topics

Genetic Pleiotropy
Models, Genetic
HSP90 Heat-Shock Proteins
Saccharomyces cerevisiae
Phenotype
Quantitative Trait Loci

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Identifiers

PMID: 42628966
DOI: 10.1093/molbev/msag215
PMCID: PMC13560073

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