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Small cell transformation of ROS1 fusion-positive lung cancer resistant to ROS1 inhibition

3 Aug 2020

Abstract excerpt

Abstract Histologic transformation from non-small cell to small cell lung cancer has been reported as a resistance mechanism to targeted therapy in EGFR-mutant and ALK fusion-positive lung cancers. Whether small cell transformation occurs in other oncogene-driven lung cancers remains unknown. Here we analyzed the genomic landscape of two pre-mortem and 11 post-mortem metastatic tumors collected from an advanced,...

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PMID: 32802958
DOI: 10.1038/s41698-020-0127-9

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