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Article

Corticostriatal dysfunction underlies diminished striatal ascorbate release in the R6/2 mouse model of Huntington's disease.

Brain research - 22 Sept 2009

Dorner Jenelle L, Miller Benjamin R, Klein Emma L, Murphy-Nakhnikian Alexander, Andrews Rachel L, Barton Scott J, Rebec George V

Abstract excerpt

A behavior-related deficit in the release of ascorbate (AA), an antioxidant vitamin, occurs in the striatum of R6/2 mice expressing the human mutation for Huntington's disease (HD), a dominantly inherited condition characterized by striatal dysfunction. To determine the role of corticostriatal fi...

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Identifiers

PMID: 19616518
DOI: 10.1016/j.brainres.2009.07.019
PMCID: PMC2745264

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19616518-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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