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Article

Ascorbate treatment attenuates the Huntington behavioral phenotype in mice.

Neuroreport - 1 Jul 2003

Rebec George V, Barton Scott J, Marseilles Ann M, Collins Kristin

Abstract excerpt

The R6/2 mouse line expresses exon 1 of the human gene for Huntington disease (HD) and shows behavioral symptoms as early as 6 weeks of age. In the striatum, a forebrain target of HD, these animals show a behavior-related deficit in extracellular ascorbate, the deprotonated form of vitamin C. We report here that this deficit may contribute to the HD behavioral phenotype. Regular injections of ascorbate (300...

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Identifiers

PMID: 12824772
DOI: 10.1097/00001756-200307010-00015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ascorbate treatment attenuates the Huntington behavioral phenotype in mice.PMID 12824772Read ↗

Dysregulation of ascorbate release in the striatum of behaving mice expressing the Huntington's disease gene.Semantic proximity Read ↗

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