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Article

Assessment of STAT5 as a potential therapy target in enzalutamide-resistant prostate cancer

13 Aug 2020

Abstract excerpt

Despite enzalutamide's efficacy in delaying the progression of metastatic castration-resistant prostate cancer (CRPC), resistance to this anti-androgen inevitably occurs. Several studies have revealed that the signal transducer and activator of transcription (STAT) 5 plays a role in tumour progression and development of drug resistance such as enzalutamide. Data mining revealed heterogeneous expression of STAT5...

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PMID: 32790723
DOI: 10.1371/journal.pone.0237248

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