Article

CDK6 is upregulated and may be a potential therapeutic target in enzalutamide-resistant castration- resistant prostate cancer by bioinformatic analysis

2022-05-12

Abstract excerpt

<h4>Background: </h4> Androgen deprivation therapy (ADT) is still the first line treatment of prostate cancer (PCa). However, after a certain period of therapy, primary PCa inevitably progresses into castration-resistant PCa (CRPC). Enzalutamide (MDV3100) is an androgen receptor (AR) signal inhibitor which can delay the progression of CRPC and increase survival of patients with metastatic CRPC. However, the mechan...

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Literature Corpus work: caaef3cd-4d2b-5cc9-8090-1fc7a6248bec
DOI: 10.21203/rs.3.rs-1501682/v2

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