Article

Discovery of PARP1-PROTAC as novel strategy against PARP inhibitor resistance via promoting ferroptosis in mutant-p53 triple-negative breast cancer

2022-03-17

Abstract excerpt

<h4>Background: </h4> and Purpose: The acquired resistance to PARP inhibitors (PARPi) caused by point mutations in PARP1 protein is hard to overcome through current strategies. In order to explore modalities to conquer resistance and identify patients who are most likely to benefit from PARP1-targeted therapy, we developed a proteolysis-targeted-chimaera (PROTAC) to degrade mutant PARP1 in p53-mutant TNBC. Experim...

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Literature Corpus work: 9bbfae65-13ff-51e4-818d-96fad9bea696
DOI: 10.22541/au.164751004.40583788/v1

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