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Article

Spatiotemporal control of gene expression in bone-marrow derived cells of the tumor microenvironment induced by MRI guided focused ultrasound.

Oncotarget - 15 Sept 2015

Fortin Pierre-Yves, Lepetit-Coiffé Matthieu, Genevois Coralie, Debeissat Christelle, Quesson Bruno, Moonen Chrit T W, Konsman Jan Pieter, Couillaud Franck

Abstract excerpt

The tumor microenvironment is an interesting target for anticancer therapies but modifying this compartment is challenging. Here, we demonstrate the feasibility of a gene therapy strategy that combined targeting to bone marrow-derived tumor microenvironment using genetically modified bone-marrow derived cells and control of transgene expression by local hyperthermia through a thermo-inducible promoter. Chimera...

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Identifiers

PMID: 26299614
DOI: 10.18632/oncotarget.4288
PMCID: PMC4695127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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