Article
LincRNA#1 knockout alone does not affect polled phenotype in cattle heterozygous for the celtic POLLED allele.
Scientific reports - 10 May 2022
Hennig Sadie L, McNabb Bret R, Trott Josephine F, Van Eenennaam Alison L, Murray James D
Abstract excerpt
A long intergenic non-coding RNA (lincRNA#1) is overexpressed in the horn bud region of polled (hornless) bovine fetuses, suggesting a potential role in horn bud suppression. Genome editing was used to test whether the absence of this sequence was associated with the horned phenotype. Two gRNAs with high mutation efficiencies targeting the 5' and the 3' regions flanking the lincRNA#1 sequence were co-injected...
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