Article
A deletion at the polled PC locus alone is not sufficient to cause a polled phenotype in cattle.
Scientific reports - 8 Feb 2022
Hennig Sadie L, Owen Joseph R, Lin Jason C, McNabb Bret R, Van Eenennaam Alison L, Murray James D
Abstract excerpt
Dehorning is a common practice in the dairy industry, but raises animal welfare concerns. A naturally occurring genetic mutation (PC allele) comprised of a 212 bp duplicated DNA sequence replacing a 10-bp sequence at the polled locus is associated with the hornless phenotype (polled) in cattle. To test the hypothesis that the 10 bp deletion alone is sufficient to result in polled, a CRISPR-Cas9 dual guide RNA...
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