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Identification of three new compounds that directly target human serine hydroxymethyltransferase 2

12 Aug 2020

Abstract excerpt

Abstract Mitochondrial serine hydroxymethyltransferase 2 (SHMT2) is an important drug target in the one‐carbon metabolic pathway, since its activity is critical for purine and pyrimidine biosynthesis. Additionally, it plays a prominent role during metabolic reprogramming of cancer cells, and SHMT2 inhibitors have proven useful as anticancer drugs. Compared to drugs targeting one‐carbon metabolic enzymes (mainly...

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PMID: 32779873
DOI: 10.1111/cbdd.13774

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