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Mutational spectra of SARS-CoV-2 orf1ab polyprotein and signature mutations in the United States of America.

Journal of medical virology - 1 Mar 2021

Banerjee Shuvam, Seal Sohan, Dey Riju, Mondal Kousik Kr, Bhattacharjee Pritha

Abstract excerpt

The pandemic COVID-19 outbreak has been caused due to SARS-CoV-2 pathogen, resulting in millions of infections and deaths worldwide, the United States being on top at the present moment. The long, complex orf1ab polyproteins of SARS-CoV-2 play an important role in viral RNA synthesis. To assess the impact of mutations in this important domain, we analyzed 1134 complete protein sequences of the orf1ab polyprotein...

Topics

Amino Acid Substitution
COVID-19
Coronavirus RNA-Dependent RNA Polymerase
Humans
Mutation
Polyproteins
Protein Conformation
SARS-CoV-2
United States
Viral Nonstructural Proteins
Viral Proteins

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PMID: 32779784
DOI: 10.1002/jmv.26417
PMCID: PMC7436414

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