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SARS-Cov-2 ORF3a: Mutability and function.

International journal of biological macromolecules - 15 Feb 2021

Bianchi Martina, Borsetti Alessandra, Ciccozzi Massimo, Pascarella Stefano

Abstract excerpt

In this study, analysis of changes of SARS-CoV-2 ORF3a protein during pandemic is reported. ORF3a, a conserved coronavirus protein, is involved in virus replication and release. A set of 70,752 high-quality SARS-CoV-2 genomes available in GISAID databank at the end of August 2020 have been scanned. All ORF3a mutations in the virus genomes were grouped according to the collection date interval and over the entire...

Topics

Amino Acid Sequence
COVID-19
Conserved Sequence
Databases, Genetic
Evolution, Molecular
Genome, Viral
Humans
Models, Molecular
Mutation
Pandemics
Protein Structure, Quaternary

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Viroporin Proteins

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Identifiers

PMID: 33359807
DOI: 10.1016/j.ijbiomac.2020.12.142
PMCID: PMC7836370

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